Increased Efficiency and Hygiene in Insulin Production

NEMO® hygienic progressing cavity pumps are designed for CIP or SIP processes

In the pharmaceutical industry, NEMO® hygienic progressing cavity pumps ensure increased efficiency and hygiene in the production of insulin and thus help to meet the growing demand. 

Globally, there are around 285 million people who suffer from diabetes according to the estimates of the International Diabetes Federation (IDF) and this figure is predicted to be 438 million by 2030.         

Look behind the scenes

Since the first insulin analogues at the end of the 1990s, there has been a constant growth in the number of preparations for diabetes treatment which are trying to get closer and closer to the way natural insulin works. They are mostly produced bio technically from recombinant DNA in various yeasts and bacteria, with numerous auxiliary materials being used in the process, including zinc chloride, hydrochloric acid and sodium hydroxide.  

Challenge accepted

This type of composition means a huge challenge for production processes: firstly, the proportions of all the substances used must be strictly adhered to in order to achieve the desired results. Secondly, the cell cultures used are extremely sensitive and shear forces can easily destroy them during conveyance making whole batches unusable. In addition to this, there are the high hygiene standards in the medical and pharmaceutical industry which must be complied with at every stage of production. The frequent and arduous cleaning cycles that are required for this do however restrict productivity.  

Excellently solved

One of the leading suppliers of insulin analogues has therefore already been using NETZSCH special hygienic progressing cavity pumps for several years to feed plate filters and convey cell mass and suspension. With a view to hygiene, the systems were specifically engineered with a conveying chamber that is as free of dead spaces as possible and designed for CIP or SIP processes. Depending on the requirement in terms of the level of hygiene, two different types of design are used, one version with a flexible rod to convey the gradient to the filters and one model with a special hygienic joint for transporting cell cultures. This pin joint is designed so that it is rinsed by the medium, which means external lubrication is not needed and a build-up of residues on the joint is prevented.

On the other hand, the flexible rod transmits the rotation of the drive without any moving parts at all, which meets even higher demands for cleanliness and sterility thanks to the absence of gaps. In addition, this design is virtually maintenance-free. The first NEMO® conveyor systems were installed in insulin production in 2002 and since then additional pumps have been added on several occasions to increase capacity. In actual fact, the maintenance intervals are five years before the stator is replaced and the rotors only have to be changed after ten years.

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Cosmetics Industry

Archaeological evidence shows that people have decorated their bodies with color since primitive times. The Egyptians however are attributed with assigning a major role to cosmetics and body cleanliness. Make-up, fats, ointments and scents were applied in conformance with societal conventions and trends that encouraged hygiene. The Greeks and Romans adopted many of these Egyptian customs; they anointed themselves with olive and almond oil, and Roman women were even known to bathe in donkey and goat milk. It wasn’t until the 19th century with the manufacture of purified wool grease - or lanolin – that the modern cosmetics industry arose.

Currently 500,000 tons of cosmetic products are manufactured annually in Germany alone. The ingredients used in cosmetics production are numerous and varied; over 7000 different substances are included on the “INCI List” (International Nomenclature of Cosmetic Ingredients) and are in use in the European Union by itself.

Some of these ingredients and categories of ingredients include: water, emulsifying agents, thickening agents, plant oils, petroleum-based products, essential oils, fresh plant extracts, tinctures, hydrosols, alcohols and even chemical ingredients with abrasive, bleaching or antimicrobial qualities.

The versatile capabilities of NEMO® Pumps have established them as indispensable in the cosmetic industry. NEMO® Pumps routinely handle plant-derived materials, highly viscous healing earth clay, substances requiring gentle and low-pulsation conveyance, products with an array of chemical characteristics, and products with various physical characteristics including abrasiveness.  Even products requiring extremely low-pressure environments (vaporization facilities and reactors) can be handled by NEMO® Pumps.

NEMO® Drum and Pail Emptying Pumps have provided residual-free container emptying even with highly viscous content. In feeding heating installations, in processing lines and filling stations, and even under strict hygienic conditions, NEMO® Pumps are specially configured to meet the requirements of each process by the experts at NETZSCH.

NEMO® Progressing Cavity Pumps to Convey PharmaceuticalsSpecial NETZSCH hygienic pumps are designed for cleanliness and smooth conveyance.


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